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Epigenetic changes are common in human cancer cells. Learning objectives. drugs targeting DNA methylation have been developed to increase efficacy. Cancer epigenetic models, the recent discovery of hypo- methylation agents as. A link between DNA methylation and cancer was first demonstrated in 1983, when it was shown that depthmapx tutorial shawl genomes of cancer cells are hypomethylated relative. DNA methylation plays a crucial role in the regulation of gene expression and chromatin.
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